blue #
= weekly pop chart peak
| 1 | Po Pimp | Oct 1996 |  |
| Do Or Die Featuring Twista |
| 2 | Emotions | May 1997 | |
| 3 | Get It Wet | Nov 1997 | |
| 4 | Still Po' Pimpin' | May 1998 | |
| Do Or Die Featuring Johnny P And Twista |
| 5 | Whatuon | Jul 1998 | |
| Latanya Featuring Twista |
| 6 | In Your World | Aug 1998 | |
| Twista & The Speedknot Mobstaz |
| 7 | Peace Of Mind | Jan 2001 | |
| Darkside Ballaz Featuring Twista |
| 8 | Slow Jamz | 6 | Feb 2004 | |
| Twista Featuring Kanye West & Jamie Foxx |
| 9 | Overnight Celebrity | 18 | May 2004 | |
| 10 | Never Really Was | Jul 2004 | |
| Mario Winans Featuring Twista |
| 11 | So Sexy | Aug 2004 | |
| Twista Featuring R. Kelly |
| 12 | Sunshine | Sep 2004 | |
| Twista Featuring Anthony Hamilton |
| 13 | Let's Go | 25 | Oct 2004 | |
| Trick Daddy Featuring Lil Jon And Twista |
| 14 | So Sexy Chapter II (Like This) | Nov 2004 | |
| Twista Featuring R. Kelly |
| 15 | Hope | Feb 2005 | |
| Twista Featuring Faith Evans |
| 16 | Gotta Make It | Aug 2005 | |
| Trey Songz Featuring Twista |
| 17 | Girl Tonite | 29 | Nov 2005 | |
| Twista Featuring Trey Songz |
| 18 | Hit The Floor | Dec 2005 | |
| Twista Featuring Pitbull |
| 19 | So Lonely | Jan 2006 | |
| Twista Featuring Mariah Carey |
| 20 | Spit Your Game | May 2006 | |
| The Notorious B.I.G. Featuring Twista And Bone Thugs-N-Harmony |
| 21 | DJ Play A Love Song | Jun 2006 | |
| Jamie Foxx Featuring Twista |
| 22 | Give It Up | Jun 2007 | |
| Twista Featuring Pharrell Williams |
| 23 | Good Sex | Jun 2007 | |
| R. Kelly Featuring Twista |
| 24 | 5000 Ones | Nov 2007 | |
| Drama Featuring Nelly - T.I. - Diddy - Yung Joc - Willie The Kid - Young Jeezy - Twista |
| 25 | Cuddy Buddy | Nov 2008 | |
| Mike Jones Featuring Trey Songz, Lil Wayne And Twista |
| 26 | Wetter (Calling You Daddy) | Aug 2009 | |
| 27 | Yo Body | 2009 | |
| Twista Featuring Do Or Die & Johnny P |
| 28 | Holiday | Aug 2010 | |
| Twista Featuring Nate Dogg |
| 29 | Make A Movie | Jan 2011 | |
| Twista Featuring Chris Brown |
| 30 | The Heat | Mar 2011 | |
| Twista Featuring Raekwon |
| 31 | Bad Girl | Apr 2011 | |
| Twista Featuring Lloyd |
| 32 | Grab Somebody | Jul 2011 | |
| Bobby V Featuring Twista |
| 33 | Worldwide Choppers | Jul 2011 | |
| Tech N9ne Featuring D-Loc, Twista, Busta Rhymes, Ceza, JL of B. Hood, Twisted Insane, USO & Yelawolf |
| 34 | Throwin My Money | Jul 2013 | |
| Twista Featuring R. Kelly |
| 35 | It's Yours | Aug 2014 | |
| Twista Featuring Tia London |